Research, Advancement of EM, Clinical, Critical Care

Critical Care Research Database - 2015 Edition

This research database is a comprehensive resource through which students, residents and fellows can develop a sound understanding of major topics in the world of critical care. Read through the landmark studies, meta-analyses, and recently-published review articles we've carefully selected, and you'll know everything there is to know about your topic of interest. Check back often! We're always adding more topics.

Acid-base Disorders An approach to complex acid-base problems: keeping it simple. Herd AM Canadian Family Physician 2005
Acid-base Disorders Metabolic acidosis in the critically ill: part 1 Morris CG Anesthesia 2008
Acid-base Disorders Metabolic acidosis in the critically ill: part 2 Morris CG Anesthesia 2008
Acute Hepatic Failure Hepatorenal syndrome and novel advances in its management. Fabrizi F Kidney Blood Press Res 2013
Acute Hepatic Failure Acute-on-chronic liver failure: current concepts on definition, pathogenesis, clinical manifestations and potential therapeutic interventions. Laleman W Expert Rev Gastroenterol Hepatol 2011
Acute Hepatic Failure Acute Liver Failure Bernal W New Engl J Med 2013
Alcohol Withdrawal Efficacy and safety of pharmacological interventions for the treatment of the Alcohol Withdrawal Syndrome. Amato L Cochrane Databse Sys Rev 2011
Alcohol Withdrawal Lorazepam for the prevention of recurrent seizures related to alcohol. D'Onofrio G New Engl J Med 1999
Alcohol Withdrawal Recognition and management of withdrawal delirium (delirium tremens). Schuckit MA New Engl J Med 2014
Analgesia and Sedation Sedation and analgesia in the mechanically ventilated patient. Patel SB Am J Respir Crit Care Med. 2012
Analgesia and Sedation Daily sedation interruption versus targeted light sedation strategies in ICU patients. Hughes CG Crit Care Med 2013
Analgesia and Sedation Dexmedetomidine: a review of its use for sedation in mechanically ventilated patients in an intensive care setting and for procedural sedation. Hoy SM Drugs 2011
Analgesia and Sedation Remifentanil : a review of its analgesic and sedative use in the intensive care unit. Battershill AJ Drugs 2006
Anaphylaxis H1-antihistamines for the treatment of anaphylaxis: Cochrane systematic review. Sheikh A Allergy 2007
Anaphylaxis Adrenaline (epinephrine) for the treatment of anaphylaxis with and without shock. Sheikh A Cochrane Database Sys Rev 2008
Anaphylaxis Glucocorticoids for the treatment of anaphylaxis. Choo KJ Cochrane Database Sys Rev 2012
Aortic Dissection Medical management of acute type A aortic dissection. Feldman M Ann Thorac Cardiovasc Surg 2009
Aortic Dissection Current management of type B aortic dissection. Tran TP Vasc Health Risk Manag 2009
Aortic Dissection Management of acute type B aortic dissection; ADSORB trial. Hughes GC J Thorac Cardiovasc Surg 2015
Acute Respiratory Distress Syndrome Meta-analysis: ventilation strategies and outcomes of the acute respiratory distress syndrome and acute lung injury. Putensen C Ann Intern Med 2009
Acute Respiratory Distress Syndrome Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. Briel M JAMA 2010
Acute Respiratory Distress Syndrome The effect of prone positioning on mortality in patients with acute respiratory distress syndrome: a meta-analysis of randomized controlled trials. Hu SL Crit Care Med 2014
Acute Respiratory Distress Syndrome Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. Steinberg KP New Engl J Med 2006
Asthma Severe refractory asthma: an update. Wener RR Eur Respir Rev 2013
Asthma Corticosteroids in the treatment of acute asthma Alangari AA Ann Thorac Med 2014
Asthma Non-invasive positive pressure ventilation for treatment of respiratory failure due to severe acute exacerbations of asthma. Lim WJ Cochrane Database Sys Rev 2012
Asthma Ketamine in status asthmaticus: A review. Goyal S Indian J Crit Care Med 2013
Asthma Management of mechanical ventilation in acute severe asthma: practical aspects. Oddo M Intensive Care Med 2006
Chronic Obstructive Pulmonary Disease Noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease. Brochard New Engl J Med 1995
Chronic Obstructive Pulmonary Disease Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease. Walters JA Cochrane Database Sys Rev 2014
Chronic Obstructive Pulmonary Disease Antibiotics for exacerbations of chronic obstructive pulmonary disease. Vollenweider DJ Cochrane Database Sys Rev 2012
Burn Management Intra-abdominal hypertension and abdominal compartment syndrome in burn patients. Ivy ME J Trauma 2000
Burn Management Burn resuscitation. Alvarado R Burns 2009
Hemorrhagic Stroke Intracranial hemorrhage: diagnosis and management. Freeman WD Neurol Clin 2012
Hemorrhagic Stroke Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage. Anderson CS NEJM 2013
Hemorrhagic Stroke Aneurysmal Subarachnoid Hemorrhage. D'Souza S J Neurosurg Anesthesiol 2014
Hemorrhagic Stroke Current options for the management of aneurysmal subarachnoid hemorrhage-induced cerebral vasospasm: a comprehensive review of the literature. Dabus G Interv Neurol 2013
Ischemic Stroke Advances in the Critical Care Management of Ischemic Stroke Singh V Stroke Res Treat 2013
Ischemic Stroke Thrombolysis for acute ischaemic stroke. Wardlaw JM Cochrane Database Sys Rev 2014
Ischemic Stroke Effects of immediate blood pressure reduction on death and major disability in patients with acute ischemic stroke: the CATIS randomized clinical trial. He J JAMA 2014
Ischemic Stroke Indications for early aspirin use in acute ischemic stroke : A combined analysis of 40 000 randomized patients from the chinese acute stroke trial and the international stroke trial. On behalf of the CAST and IST collaborative groups. Chen ZM Stroke 2000
Ischemic Stroke Randomized assessment of rapid endovascular treatment of ischemic stroke. Goyal M New Engl J Med 2015
Traumatic Intracranial Hemorrhage Critical care management of severe traumatic brain injury in adults. Haddad SH Scand J Trauma Resusc Emerg Med. 2012
Traumatic Intracranial Hemorrhage Specific intensive care management of patients with traumatic brain injury: Present and future Chowdhury T Saudi J Anaesthesia 2014
Diabetic Ketoacidosis/Hyperosmolar, Hyperglycemic Nonketotic Syndrome Diabetic ketoacidosis: diagnosis and management. Fasanmade OA Afr J Med Sci 2008
Diabetic Ketoacidosis/Hyperosmolar, Hyperglycemic Nonketotic Syndrome Hyperglycemic Crises in Adult Patients with Diabetes Kitabchi AE Diabetes Care 2009
Diabetic Ketoacidosis/Hyperosmolar, Hyperglycemic Nonketotic Syndrome Hyperglycemic Hyperosmolar Syndrome in Children: Pathophysiological Considerations and Suggested Guidelines for Treatment Zeitler P pediatric endocrine society 2010
Heart failure The 2012 Canadian Cardiovascular Society Heart Failure Management Guidelines Update: Focus on Acute and Chronic Heart Failure McKelvie RS Canadian Journal of Cardiology 2013
Heart failure Continuous versus bolus intermittent loop diuretic infusion in acutely decompensated heart failure: a prospective randomized trial. Palazzouli A Critical Care 2014
Hyper- and Hypo- kalemia Pathogenesis, diagnosis and management of hyperkalemia Lehnhardt A Pediatr Nephrol 2011
Hyper- and Hypo- kalemia Hyperkalemia: A Review Greenberg A J Intensive Care Med 2005
Hyper- and Hypo- natremia Management of Hyponatremia in the ICU. Sterns RH Chest 2013
Hyper- and Hypo- natremia Hypernatremia Adrogue HJ New Engl J Med 2000
Hypoxemia Guidelines for standards of care for patients with acute respiratory failure on mechanical ventilatory support. Task Force on Guidelines; Society of Critical Care Medicine Society of Critical Care Medicine Crit Care Med. 1991
Myxedema coma Myxedema coma: a new look into an old crisis. Chowdhury S J Thyroid Res 2011
Neuroleptic Malignant Syndrome Neuroleptic Malignant Syndrome. Strawn JR Am J Psychiatry 2007
Nutrition Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) J Parenter Enteral Nutr. 2009
Nutrition Trial of the route of early nutritional support in critically ill adults. Harvey SE New Engl J Med 2014
Pancreatitis American College of Gastroenterology Guideline: Management of Acute Pancreatitis Vege SS Am J Gastroenterol 2013
Post arrest Therapeutic Hypothermia Targeted Temperature Management at 33¡C versus 36¡C after Cardiac Arrest (TTM study) Nielsen N New Engl J Med 2013
Post arrest Therapeutic Hypothermia Therapeutic Hypothermia after Out-of-Hospital Cardiac Arrest in Children Moler FW New Engl J Med 2015
Post arrest Therapeutic Hypothermia Effect of Prehospital Induction of Mild Hypothermia on Survival and Neurological Status Among Adults With Cardiac Arrest: A Randomized Clinical Trial. Kim F JAMA 2013
Pulmonary Embolism Management of Massive and Submassive Pulmonary Embolism, Iliofemoral Deep Vein Thrombosis, and Chronic Thromboembolic Pulmonary Hypertension: A Statement from the American Heart Association. Jaff MR Circulation 2011
Pulmonary Embolism Thrombolytic treatment for pulmonary embolism. Dong B Cochrane Database 2006
Pulmonary Embolism Subcutaneous low-molecular-weight-heparin compared with continuous intravenous heparin in the treatment of proximal vein thrombosis Hull RD New Engl J Med 1992
Resuscitation A comparison of albumin and saline for fluid resuscitation in the intensive care unit. Finfer S New Engl J Med 2004
Resuscitation Comparison of dopamine and norepinephrine in the treatment of shock. De Backer D New Engl J Med  
Resuscitation Preoxygenation and Prevention of Desaturation During Emergency Airway Management Weingart SD Annals of Emergency Medicine 2012
Sepsis/Septic Shock Early goal directed therapy in the treatment of severe sepsis and septic shock. Rivers M New Engl J Med 2001
Sepsis/Septic Shock A Randomized Trial of Protocol-Based Care for Early Septic Shock (ProCESS study) The ProCESS Investigators New Engl J Med 2014
Sepsis/Septic Shock Lactate Clearance vs Central Venous Oxygen Saturation as Goals of Early Sepsis Therapy Jones AE JAMA 2010
Sepsis/Septic Shock Fluid resuscitation in severe sepsis and septic shock: an evidence-based review Vincent JL Crit Care Med 2004
Status epilepticus Lorazepam vs Diazepam for Pediatric Status Epilepticus: A Randomized Clinical Trial. Chamberlain JM JAMA 2014
Status epilepticus Anticonvulsant therapy for status epilepticus Prasad M Cochrane 2014
Status epilepticus Status Epilepticus Cherian A Annals of Indian Academy of Neurology 2009
Thyroid storm Clinical concepts on thyroid emergencies Papi G Front Endocrinol 2014
Toxicology Intravenous lipid emulsion in clinical toxicology Rothschild L Scandiv Jrnl of Trauma, Resus, and Em Med 2010
Toxicology Toxicology in the ICU: Part 1: General Overview and Approach to Treatment Levine M Chest 2011
Toxicology Toxicology in the ICU: Part 2: Specific Toxins Brooks DE Chest 2011
Toxicology Serotonin toxicity: a practical approach to diagnosis and treatment. Isbister GK MJA 2007
Toxicology Tricyclic antidepressant overdose: a review. Kerr GW Emerg Med J 2001
Toxicology An evidence based flowchart to guide the management of acute salicylate (aspirin) overdose Dargan PI Emerg Med J 2002
Toxicology A review of acetaminophen poisoning. Hodgman MJ Crit Care Clin 2012
Toxicology Treatment for calcium channel blocker poisoning: A systematic review St-onge M Clinical Toxicology 2014
Toxicology Management of acute organophosphorus pesticide poisoning Eddleston M Lancet 2008
Toxicology A Systematic Review of Ethanol and Fomepizole Use in Toxic Alcohol Ingestions Beatty L Emerg Med International 2013
Toxicology Review article: Management of cyanide poisoning. Reade MC Emerg Med Australia 2012
Upper GI/Variceal Bleeding Management of Gastric Varices Garcia-Pagan JC Clinical Gastroenterology and Hepatology 2014
Upper GI/Variceal Bleeding Omeprazole before endoscopy in patients with gastrointestinal bleeding. Lau JY New Engl J Med 2007
Upper GI/Variceal Bleeding Transfusion Strategies for Acute Upper Gastrointestinal Bleeding. Villanueva C New Engl J Med 2013