Browsing: Toxicology

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Dermatology , Hematology , Oncology , Toxicology

Warfarin-Induced Skin Necrosis: Not Your Typical Rash

4/15/2023 Brandon Murdock, MD , Chung-ting J. Kou , Paul A. Gonzales , David M. Crawford
Warfarin-induced skin necrosis (WISN) is a rare condition thought to be due to microvascular thrombosis and ischemia and is commonly related to protein C deficiency. Recognition of WISN is critical to
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Toxicology

I Ordered the Urine Drug Screen, Now What? An Overview on Testing, Interference, and Utility of UDS in the ED

4/15/2023 E. Mason Jackson, MD , Lindsay Davis, DO, MPH, NRP , Alexa Peterson, DO, MS
The urine drug screen is a widely used, but imperfect, diagnostic test. Because of its potential flaws, it should not be used out of context or in isolation, but it remains a valuable test in the tool
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Toxicology

Top Gun Toxicity: Military-Grade Hydrocarbon Exposure Management in the ED

1/30/2023 E. Mason Jackson, MD , Michael Troise, MD
The ramifications of military fuel leaks extend beyond environmental disasters to acute exposures/ingestions and chronic toxicity. With more than 450 military bases in the United States, many of which
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Toxicology , Nephrology

A Case of Intentional Salt Ingestion Leading to Life-Threatening Hypernatremia

1/30/2023 Christopher M Mashiak, MD , Johndavid M Storn, MD , Jennifer V Pope, MD
Acute salt ingestion should be rapidly corrected to reduce serum osmolality. This can be done with an infusion of hypotonic solutions, such as 5% dextrose in water (D5W), with a goal reduction of 1 mm
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Toxicology

Buprenorphine Induction: Where We Are and Where We’re Headed

10/10/2022 Lance Shaull, MD
Buprenorphine has been shown to be a safe and effective medication in multiple settings with extensive research on both unobserved induction and physician-observed induction. Emerging evidence suggest
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Toxicology

TCA Overdoses and Mimics: Don’t Delay, Don’t Be Led Astray

8/10/2022 Lance Shaull, MD , Andrew Mittelman, MD
At toxic doses, tricyclic antidepressants (TCAs) cause blockade of sodium channels, muscarinic receptors, and alpha-adrenergic receptors. Slowed ventricular contraction, tachycardia, and vasodilation
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Cardiology , Toxicology

Torsades de Pointes after Olanzapine Use for Agitation

4/10/2022 Joshua Hall, DO , Nauman Rashid
Second-generation antipsychotics are becoming more commonly used because of their safety profiles. Nevertheless, this case demonstrates a risk of QTc prolongation and torsades de pointes with olanzapi
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Social EM , Toxicology

Coastal Harmful Algal Blooms and Climate Change – Toxic Challenges for Emergency Medicine

4/10/2022 Catharina Giudice, MD , Caitlin S Rublee, MD, MPH , Priya Srihari, MD
Climate health and public health are linked in ways that become more obvious every year. In this context, we will summarize the marine toxins that are sending more patients to the emergency department
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Toxicology

Bupropion Toxicity

4/10/2022 E. Mason Jackson, MD , Erik Fisher, MD, FACEP
Initially marketed as an atypical antidepressant for adults, bupropion gained popularity for its use in tobacco cessation and for its lack of sexual side effects commonly seen with other typical antid
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Toxicology , COVID-19

The Toxicology of COVID

4/10/2022 Michael Keenan, MD , Vincent Calleo, MD
Emergency physicians have watched with excitement the rapid development of COVID-19 vaccines. However, while we were watching the rapid scientific development, there was a concurrent wave of misguided