Browsing: Critical Care Alert

Can prophylactic antibiotics affect the incidence of ventilator-associated pneumonia following out-of-hospital cardiac arrest?
The VITAMINS Trial looked at the role of vitamin C, thiamine, and hydrocortisone in saving patients with septic shock. It's the first randomized controlled trial focused on whether vitamins can provid
The ICU-ROX study, designed as the largest RCT of mechanically ventilated ICU patients, investigates whether conservative oxygen therapy could reduce mortality. Are the results enough to tip the scale
This review article was trying to take another look at the impact of epinephrine, especially its impact on meaningful neurologic survival, to see if the debates launched by the PARAMEDIC-2 trial were
Can vitamin C benefit patients with sepsis-related ARDS? Take a look at the evidence from the CITRIS-ALI study before you take a stance in this ongoing debate.
Sometimes a clinical trial shows no statistical differences yet can help to illuminate best practices. Count the ESETT Trial as one of them.
Moderate therapeutic hypothermia could be another tool in treating cardiac arrest patients. But how much should a patient be cooled? The HYPERION Trial doesn't resolve that debate.
Released in October 2019, CRASH-3 is the latest trial exploring the benefits of tranexamic acid, this time in traumatic brain injury. The bottom line: TXA hasn't been shown to reduce mortality.
The SEP-1 core measure instituted by CMS has been hotly debated. A new review of literature shows a lack of high-quality evidence to back up the specificity required in the sepsis bundle.
Fluid resuscitation guidelines for severe sepsis and septic shock presently address only the initial phase of resuscitation. The RIFTS trial examines the efficacy of a restrictive IV fluid resuscitati