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The leading cause of iatrogenic pneumothorax is transthoracic needle aspiration. In our case, however, pneumothorax was most likely due to transbronchial lung biopsy two days prior to presentation. Although our patient had a tension pneumothorax, it is worth noting that post‐pneumonectomy syndrome (PPS) is a rare post-pneumonectomy complication occurring typically within several months and caused by excessive mediastinal shifting that results in airway compression.